The deal is part of Twitter's "Amplify" program, which lets TV broadcasters show ad-supported video clips in users' Twitter feeds.
The NFL and Twitter say the deal will let football fans interact with NFL video content created specifically for Twitter — on computers, tablets or mobile devices. The league says content will include highlights from in-game highlights from NFL Network's Thursday Night Football and clips from other regular season and postseason games.
There will also be news, analysis fantasy football advice and other content.
The NFL says this is the first time it has partnered with a social media company.