"It's great to be married, the ceremony was beautiful and it was so special to be surrounded by our family and friends," the couple said in a statement released Friday to People magazine.
Biel spokeswoman Meredith O'Sullivan Wasson confirmed the report.
The 31-year-old Timberlake and 30-year-old Biel were wed in southern Italy. The couple got engaged in December after dating for several years.
Timberlake, who has been acting more than singing lately, stars in the Clint Eastwood baseball film, "The Trouble with the Curve." Biel stars in the remake of "Total Recall." She will next be seen in "Hitchcock."